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We routinely post information that may be important to investors on our business, operations and financial results, that are subject to substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements.

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What should I tell my health care provider before I take Pristiq?

You should not use Desvenlafaxine if you are allergic to desvenlafaxine or venlafaxine (Effexor), or if you are being treated with methylene blue injection.

Do not use Desvenlafaxine if you are taking an MAO inhibitor. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. You must wait at least 14 days after stopping an MAOI before you can take Desvenlafaxine. After you stop taking Pristiq, you must wait at least 7 days before you start taking an MAOI.

To make sure Desvenlafaxine is safe for you, tell your doctor if you have:

• bipolar disorder (manic depression);
• liver or kidney disease;
• heart disease, high blood pressure, high cholesterol, or a history of stroke;
• glaucoma;
• seizures or epilepsy;
• a history of stroke;
• a bleeding or blood clotting disorder;
• low levels of sodium in your blood; or
• if you are switching to Desvenlafaxine from another antidepressant.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using Desvenlafaxine. Your family or other caregivers should also be alert to changes in your mood or symptoms.

FDA pregnancy category C. Desvenlafaxine may cause problems in a newborn baby if the mother takes the medication late in pregnancy (during the third trimester). Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Desvenlafaxine can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Do not give this medication to anyone under 18 years old without the advice of a doctor.

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