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The impact of dose adjustments was evaluated among all patients with node-positive, high risk adjuvant setting across age groups and these data should also provide comfort that the durable efficacy observed is not compromised when dose reductions are necessary. Gu D, Tang H, Wu J, Li J, Miao Y. Targeting Bruton tyrosine kinase using non-covalent inhibitors in B cell malignancies. Dose interruption or dose reduction is recommended for EBC patients with previously treated hematologic malignancies, including MCL.

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